Drugs Avoided in Patients with Renal Failure

Drugs Avoided in Patients with Renal Failure ➧ The excretion of water-soluble drugs and their active metabolites will be impaired. For drugs that are renally excreted the half-life increases slowly with deteriorating renal function until severe nephron loss at which point the half-life increases sharply with further reductions in renal function. Dialysis can only...

Read More

Drugs affecting IOP

Drugs affecting IOP ➧ Normal intraocular pressure (IOP) is between (10 - 20 mmHg). The average value of IOP is 15.5 mmHg with fluctuations of about 2.75 mmHg. ➧ IOP also varies with other factors such as heart rate, respiration, fluid intake, systemic medication, and topical drugs. ➧ Intraocular vascular tone is predominantly affected by CO₂; hypocarbia decreases...

Read More

Drugs with Rebound Phenomenon

Drugs with Rebound Phenomenon ➧ The rebound effect, or rebound phenomenon, is the tendency of some medications, in sudden discontinuation, to cause a return of the symptoms it relieved, to a degree stronger than they were before treatment first began. Medications with a known rebound effect can be withdrawn gradually, or, in conjunction with another medication that...

Read More